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Role of Lipooligosaccharide in the Attachment of Moraxella catarrhalis to Human Pharyngeal Epithelial Cells
Author(s) -
Akgul Gulcan,
Erturk Ali,
Turkoz Mustafa,
Turan Tolga,
Ichinose Akitoyo,
Nagatake Tsuyoshi,
Ahmed Kamruddin
Publication year - 2005
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2005.tb03685.x
Subject(s) - moraxella catarrhalis , microbiology and biotechnology , moraxella (branhamella) catarrhalis , bacterial adhesin , moraxella , biology , pilus , mutant , virulence , bacteria , gene , haemophilus influenzae , genetics , antibiotics
The goal of this study was to determine the role of lipooligosaccharide in the attachment of Moraxella catarrhalis to human pharyngeal epithelial cells. Strain 2951 and its P k mutant strain 2951 galE were used in this study. This study suggests that the P k epitope of LOS is not an adhesin for M. catarrhalis , but plays a crucial role by its surface charge in the initial stage of attachment.