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A Novel B‐2 Suppressor Cell Regulating Susceptibility/Resistance of Mice to Toxoplasma gondii Infection
Author(s) -
Mun HyeSeong,
Aosai Fumie,
Fang Hao,
Piao LianXun,
Winn Tin,
Norose Kazumi,
Yano Akihiko
Publication year - 2005
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2005.tb03674.x
Subject(s) - toxoplasma gondii , biology , suppressor , microbiology and biotechnology , toxoplasmosis , immunology , virology , antibody , gene , genetics
Irradiation treatment enhanced resistance of C57BL/6, but not BALB/c against Toxoplasma gondii infection. Six Gy‐irradiated (IR) C57BL/6 recipients of B‐2 cells from T. gondii ‐infected C57BL/6 died after infection. B‐2 suppressor cells from infected C57BL/6 enhanced production of IL‐4 and IL‐10 in peritoneal exudate cells (PECs), and down‐regulated NO release in peritoneal macrophages after infection. On the other hand, B‐2 suppressor cells were not detected in a strain, BALB/c, resistant against infection. These data indicated that irradiation‐sensitive B‐2 cells regulated susceptibility/resistance in mice against T. gondii infection.