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Study on Immunological Status of Chinese HIV‐Infected Individuals
Author(s) -
Shang Hong,
Jiang Yongjun,
Zhang Zining,
Han Xiaoxu,
Zhang Min,
Wang Yanan,
Liu Jing
Publication year - 2004
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2004.tb03606.x
Subject(s) - elispot , immunology , ctl* , cd8 , immune system , flow cytometry , biology , t cell , viral load , lentivirus , human immunodeficiency virus (hiv) , disease , cytokine , immunopathology , virology , medicine , viral disease
HIV‐1 infection is characterized by a gradual decline of immune function, and the immune dysfunction is widely regarded as one of the most important determinants of disease progression. The present study was performed to analyze in more detail the immunological status of HIV‐infected people in China. T cell counts, activation of T cells, HIV‐1 specific CTL and plasma levels of cytokines were determined with flow cytometry, IFN‐γ Elispot or ELISA techniques. The HIV viral load was negatively correlated with CD4 + , CD8 + T cell counts ( r = –0.654, P <0.001; r = –0.228, P <0.05); the breadth and magnitude of HIV‐1 specific CTL responses against HIV‐1 Gag peptides was related to disease progression; the activation of CD8 + T cells was significantly higher than that in HIV‐negative controls; the level of plasma IL‐12 was much lower and the plasma IFN‐γ, IL‐10 and IL‐6 were much higher in HIV‐infected persons than in HIV‐negative controls ( P <0.05). Study on immunological status in HIV‐infected Chinese is very important in predicting the disease progression and providing information for HAART therapy in China.