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Reliability of the Detection of Meningococcal γ‐Glutamyl Transpeptidase as an Identification Marker for Neisseria meningitidis
Author(s) -
Takahashi Hideyuki,
Kuroki Toshiro,
Watanabe Yuko,
Dejsirilert Surang,
Saengsuk Leelaowadee,
Yamai Shiro,
Watanabe Haruo
Publication year - 2004
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2004.tb03540.x
Subject(s) - neisseria meningitidis , microbiology and biotechnology , biology , neisseriaceae , strain (injury) , mutant , bacteria , biochemistry , gene , genetics , antibiotics , anatomy
Detection of γ‐glutamyl transpeptidase (GGT; ggt ) activity is one of the useful methods for a specific identification of Neisseria meningitidis . However, we previously happened to isolate a ggt ‐deficient N. meningitidis strain (NIID113) from a healthy carrier. In this study, in order to re‐examine the reliability of the marker, we again investigated the GGT activity of 245 N. meningitidis human isolates and identified two other GGT‐defective N. meningitidis isolates besides NIID113. The isolation frequency (1.2%) of ggt mutants among human isolates strongly confirmed the 98.8% reliability of GGT activity as the identification marker for N. meningitidis .