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Herpes Simplex Virus UL14 Protein Blocks Apoptosis
Author(s) -
Yamauchi Yohei,
Daikoku Tohru,
Goshima Fumi,
Nishiyama Yukihiro
Publication year - 2003
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2003.tb03432.x
Subject(s) - apoptosis , herpes simplex virus , biology , heat shock protein , virus , virology , cell culture , function (biology) , microbiology and biotechnology , genetics , gene
We report that an HSV‐2 UL14 protein expressing cell line (14/HEp‐2) was more resistant to apoptosis induced by osmotic shock and certain drugs than its parental cell line. Furthermore, HSV‐1 UL14 protein deletion virus (UL14D) showed weaker inhibition of apoptosis compared to the rescued virus UL14R. The protein' s anti‐apoptotic function may derive from its heat shock protein‐like properties.