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The Inhibitory Effect of Essential Oils on Herpes Simplex Virus Type‐1 Replication In Vitro
Author(s) -
Minami Masato,
Kita Masakazu,
Nakaya Takaaki,
Yamamoto Toshiro,
Kuriyama Hiroko,
Imanishi Jiro
Publication year - 2003
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2003.tb03431.x
Subject(s) - herpes simplex virus , vero cell , biology , essential oil , viral replication , in vitro , virology , virus , incubation , microbiology and biotechnology , biochemistry , food science
The antiviral effect of 12 essential oils on herpes simplex virus type‐1 (HSV‐1) replication was examined in vitro . The replication ability of HSV‐1 was suppressed by incubation of HSV‐1 with 1% essential oils at 4 C for 24 hr. Especially, lemongrass completely inhibited the viral replication even at a concentration of 0.1%, and its antiviral activity was dependent on the concentrations of the essential oil. When Vero cells were treated with the essential oil before or after viral adsorption, no antiviral activity was found, which suggests that the antiviral activity of essential oils including lemongrass may be due to the direct interaction with virions.