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Prevalence of Inherited Myeloperoxidase Deficiency in Japan
Author(s) -
Nunoi Hiroyuki,
Kohi Fumikazu,
Kajiwara Hideki,
Suzuki Kazuo
Publication year - 2003
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2003.tb03414.x
Subject(s) - autoanalyzer , myeloperoxidase , hematology , immunology , biology , medicine , inflammation
The microbicidal activity of the myeloperoxidase (MPO)‐hydrogen peroxide‐halide system has been implicated as the most efficient, oxygen‐dependent antimicrobial component of neutrophil host defense. Unexpectedly, individuals with MPO deficiency suffer few clinical consequences. In order to understand better the clinical impact of MPO deficiency, we surveyed several clinical hematology laboratories in Japan to assess the prevalence of MPO deficiency in the general population. MPO activity was determined by flow cytometry using the Technicon H series of automated systems. We identified 26 cases of complete MPO deficiency, prevalence 1 in 57,135, and 129 cases of partial deficiency, prevalence 1 in 17,501. The distribution of complete and partial deficiencies differed among the laboratories studied.