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Achievement of Complete Mycological Cure by Topical Antifungal Agent NND‐502 in Guinea Pig Model of Tinea Pedis
Author(s) -
Uchida Katsuhisa,
Tanaka Takashi,
Yamaguchi Hideyo
Publication year - 2003
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2003.tb02797.x
Subject(s) - trichophyton , antifungal , dermatophyte , guinea pig , antifungal drugs , medicine , dermatology , biology , microbiology and biotechnology
We examined the therapeutic effect of a 1% cream preparation of NND‐502, a novel topical antifungal agent, in a guinea pig tinea pedis model produced by infecting the plantar skin of guinea pigs with Trichophyton mentagrophytes . Animals developing tinea pedis were divided into two groups: an untreated control group and a treated group. In the latter group, after confirming infection had been established, the infected animals were topically treated with the NND‐502 cream once daily for one week. The animals were reared in a clean environment free from exposure to exogenous dermatophytes. At one week (5 weeks post‐infection), 6 weeks (10 weeks post‐infection) and 16 weeks (20 weeks post‐infection) after completion of the treatment, plantar skin samples were taken from a certain number of both groups of animals. The results demonstrated that all of the animals in the untreated control group and none of those in the treated group were culture‐positive in this animal model of tinea pedis. The topical treatment with NND‐502 achieved a mycological cure. Thus NND‐502 can be considered a promising candidate as a new anti‐dermatophytic agent for topical use.