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Identification of Staphylococcus xylosus Isolated from C57BL/6J‐ Nos2 tm1Lau Mice with Dermatitis
Author(s) -
Won Young Suk,
Kwon Hyo Jung,
Oh Goo Taeg,
Kim Bang Hyun,
Lee Chul Ho,
Park Yong Ho,
Hyun Byung Hwa,
Choi Yang Kyu
Publication year - 2002
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2002.tb02744.x
Subject(s) - staphylococcus xylosus , biology , staphylococcus , identification (biology) , microbiology and biotechnology , staphylococcus aureus , genetics , bacteria , ecology
Coagulase negative staphylococci (CNS) are significant pathogens, particularly in medical device related infections and in immunocompromised patients. Five CNS strains were isolated from 5 NOS2 knockout mice with dermatitis. Histologically, granulomatous dermatitis was found in the skin around the ear with epidermal ulceration. Dermal lesions included pustules, necrosis, and accumulations of neutrophils and macrophages. Isolates of the bacterial strains were identified to be Staphylococcus xylosus by the API STAPH kit and 16S–23S intergenic transcribed spacer‐PCR. These results demonstrate the potential of this organism to be an opportunistic pathogen in immunocompromised mice.