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Genetic Analysis of Rabies Virus Isolates in the Philippines
Author(s) -
Nishizono Akira,
Mannen Kazuaki,
ElioVilla Luningning P.,
Tanaka Seiichi,
Li Kangsheng,
Mifune Kumato,
Arca Benito F.,
Cabanban Arturo,
Martinez Benjamin,
Rodriguez Arlito,
Atienza Victor C.,
Camba Rolando,
Resontoc Nilo
Publication year - 2002
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2002.tb02714.x
Subject(s) - biology , rabies , rabies virus , phylogenetic tree , nucleoprotein , virology , lineage (genetic) , virus , genetic analysis , phylogenetics , genetic variation , gene , genetics
To determine the genetic characteristics of the rabies virus in the Philippines, 59 rabies virus isolates were obtained from domestic rabid dogs and their partial nucleotide sequences of nucleoprotein (N) gene were compared. Based on comparison with reported sequences, phylogenetic analysis revealed that all isolates from the Philippines had close genetic relations and formed two subgroups. The Philippines isolates belonged to a different lineage from other Asian isolates but were closer to them than to terrestrial isolates and laboratory strains. Several specific nucleotide and amino acid substitutions were observed among the Philippines isolates. Our results suggest that rabies viruses in the Philippines might have a characteristic evolution.