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Minimal Contribution of Vα14 Natural Killer T Cells to Th1 Response and Host Resistance against Mycobacterial Infection in Mice
Author(s) -
Kawakami Kazuyoshi,
Kinjo Yuki,
Uezu Kaori,
Yara Satomi,
Miyagi Kazuya,
Koguchi Yoshinobu,
Nakayama Toshinori,
Taniguchi Masaru,
Saito Atsushi
Publication year - 2002
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2002.tb02687.x
Subject(s) - biology , mycobacterium bovis , host (biology) , immunology , microbiology and biotechnology , mycobacterium tuberculosis , host response , natural killer t cell , host resistance , tuberculosis , interferon gamma , immune system , virology , t cell , medicine , ecology , pathology
We elucidated the contribution of Vα14 NKT cells to Th1 response and host resistance against mycobacterial infection. In Vα14 NKT cell‐deficient mice, host defense and DTH response to Mycobacterium bovis BCG were not different from wild‐type mice after pulmonary infection. There was no significant difference in the lung concentrations of IFN‐γ between the two strains of mice. In addition, host defense to systemic infection with M. tuberculosis was similar to that of M. bovis . Our results indicate that Vα14 NKT cells play only a marginal role, if any, in the Th1 response and host resistance to mycobacterial infection.