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Protective Effect of Wogonin on Endotoxin‐Induced Lethal Shock in D ‐Galactosamine‐Sensitized Mice
Author(s) -
Van Dien Mai,
Takahashi Kazuko,
Mu Mya Mya,
Koide Naoki,
Sugiyama Tsuyoshi,
Mori Isamu,
Yoshida Tomoaki,
Yokochi Takashi
Publication year - 2001
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2001.tb01311.x
Subject(s) - wogonin , lipopolysaccharide , scutellaria baicalensis , pharmacology , tumor necrosis factor alpha , nitric oxide , chemistry , medicine , immunology , endocrinology , pathology , alternative medicine , traditional chinese medicine
The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)‐induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D ‐galactosamine ( D ‐GalN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D ‐GalN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)‐α. The reduction was more marked in mice injected with D ‐GalN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D ‐GalN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF‐α and nitric oxide in LPS‐stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D ‐GalN and LPS is discussed.