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A Role for Lipid Rafts in Immune Cell Signaling
Author(s) -
Katagiri Yohko U.,
Kiyokawa Nobutaka,
Fujimoto Junichiro
Publication year - 2001
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2001.tb01259.x
Subject(s) - lipid raft , microbiology and biotechnology , signal transduction , biology , cell surface receptor , raft , receptor , cell signaling , cell membrane , phosphorylation , immune system , tyrosine kinase , cell , immunology , chemistry , biochemistry , organic chemistry , copolymer , polymer
Cross‐linking of surface receptors in hematopoietic cells results in the enrichment of these receptors in the rafts along with other downstream signaling molecules. A possible explanation how signal is transduced through the plasma membrane has arisen from the concept of raft. From the study of cellular responses in the plasma membrane which enrich members of the Src‐family tyrosine kinase, rafts can function as centers of signal transduction by forming patches. Under physiological conditions, these elements synergize to transduce successfully a signal at the plasma membrane. Rafts are suggested to be important in controlling appropriate protein interactions in hematopoietic cells, and aggregation of rafts following receptor ligation may be a general mechanism for promoting immune cell signaling.