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Decline in the HIV‐1 Isolation Rate in Japan: A 12‐Year Observation
Author(s) -
Nakasone Tadashi,
Takamatsu Junki,
Watanabe Kuhomi,
Naganawa Satoshi,
Someya Kenji,
Yoshino Naoto,
Kaizu Masahiko,
Ohsu Takeaki,
Takizawa Mari,
Izumi Yasuyuki,
Kawahara Mamoru,
Hara Takashi,
Fujimura Yoshihiro,
Yamada Kaneo,
Nagai Yoshiyuki,
Yamazaki Shudo,
Honda Mitsuo
Publication year - 2000
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2000.tb02588.x
Subject(s) - human immunodeficiency virus (hiv) , isolation (microbiology) , biology , demography , virology , bioinformatics , sociology
Since 1988, we have isolated HIV‐1 from 614 HIV‐1‐infected persons (total sample = 2,785) in Japan. During the past 12 years, we have found a decline in the HIV‐1 isolation rate in Japan, with two identifiable turning points, 1991–1992 and 1996–1997. The two turning points correspond to shifts in anti‐HIV‐1 therapy. These findings suggest that HIV‐1 in Japan is currently biologically well controlled, probably due to anti‐HIV‐1 therapy. On the other hand, this decline is inconsistent with the recent increase of genetic drug‐resistant HIV‐1 in Japan. Further studies are needed to clarify mechanisms that might explain the discrepancy.