Premium
Giraffe Strain of Pestivirus: Its Taxonomic Status Based on the 5′‐Untranslated Region
Author(s) -
Harasawa Ryô,
Giangaspero Massimo,
Ibata Georgina,
Paton David J.
Publication year - 2000
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2000.tb02583.x
Subject(s) - pestivirus , biology , phylogenetic tree , virology , virus , strain (injury) , phylogenetics , five prime untranslated region , untranslated region , classical swine fever , genetics , flaviviridae , viral disease , gene , rna , anatomy
The 5′‐untranslated region (5′‐UTR) of the ‘Giraffe’ strain of pestivirus was sequenced for comparison with those of other pestiviruses from cattle, sheep, goats, and swine. A phylogenetic tree constructed with these strains suggested that the ‘Giraffe’ strain was allocated to a new taxon. This observation was also confirmed by a newly proposed method based on palindromic nucleotide substitutions (PNS) at the three variable regions in the 5′‐UTR. Other reported pestivirus strains isolated from deer were assigned as bovine viral disease virus (BVDV)‐1 according to the PNS as well as phylogenetic analysis, suggesting that BVDV‐1 strains can cross‐infect deer as well as cattle, sheep, goats, and swine, and that wild deer may serve as a reservoir of BVDV‐1. We also identified the genovar of a deer isolate, SH9/11, as BVDV‐1c by the PNS method.