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CPR‐Total (TAFI and Activated TAFI) Levels in Plasma/Serum of Hemophiliacs
Author(s) -
Guo Xiaoyan,
Okada Noriko,
Okada Hidechika
Publication year - 2000
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.2000.tb01249.x
Subject(s) - fibrinolysis , coagulation , fibrin , in vivo , in vitro , immunology , plasma levels , medicine , biology , biochemistry , microbiology and biotechnology
Arginine carboxypeptidase (CPR) is a single‐chain plasma protein generated during coagulation from a precursor (proCPR). proCPR is the same molecule as thrombin activable fibrinolysis inhibitor (TAFI), which retards fibrin clot lysis in vitro and most likely modulates fibrinolysis in vivo . In this study, the amount of CPR‐total, which includes proCPR (TAFI) and CPR (activated TAFI), in hemophiliac patients was evaluated using a newly developed enzyme linked immunosorbent assay (ELISA). The amount of CPR‐total in plasma or serum of most of the hemophiliac patients was in the range of healthy individuals. There was no significant difference in hemophiliac patients with or without HIV‐1 infection. However, two out of the 74 hemophiliac patients showed a significantly high level. The upregulation of CPR‐total might contribute to compensate for inefficient coagulation in some hemophiliac individuals.