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Complement Receptor Type 3 Plays an Important Role in Development of Protective Immunity to Primary and Secondary Corynebacterium pseudotuberculosis Infection in Mice
Author(s) -
Lan Dinh Thi Bich,
Makino SouIchi,
Shirahata Toshikazu,
Yamada Manabu,
Nakane Akio
Publication year - 1999
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1999.tb03367.x
Subject(s) - biology , corynebacterium pseudotuberculosis , complement receptor , microbiology and biotechnology , immunity , monoclonal antibody , inflammation , immunology , antibody , complement system , immune system , bacteria , genetics
The present study was performed to investigate the role of CR3, the type 3 complement receptor, in host defense against primary and secondary Corynebacterium ( C .) pseudotuberculosis infection in mice. Treatment of mice with 5C6, an anti‐CR3 monoclonal antibody (mAb), resulted in unrestricted multiplication of bacteria in the organs and dramatically increased mortalities of the infected mice. Histological examinations showed the inflammation, degeneration and necrosis of organs and revealed that the infection‐enhancing effect of 5C6 mAb was associated with the failure of mice to focus mononuclear phagocytes at sites of bacterial multiplication. These results suggest that CR3 plays an important role in host defense against primary as well as secondary C. pseudotuberculosis infection in mice.