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Borna Disease Virus Infection in Two Family Clusters of Patients with Chronic Fatigue Syndrome
Author(s) -
Nakaya Takaaki,
Takahashi Hirokazu,
Nakamura Yurie,
Kuratsune Hirohiko,
Kitani Teruo,
Machii Takashi,
Yamanishi Koichi,
Ikuta Kazuyoshi
Publication year - 1999
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1999.tb02456.x
Subject(s) - chronic fatigue syndrome , antibody , daughter , immunology , virus , disease , peripheral blood mononuclear cell , virology , viral disease , biology , medicine , genetics , evolutionary biology , in vitro
A high rate of Borna disease virus (BDV) infection has been demonstrated in patients with chronic fatigue syndrome (CFS). Herein, we focused on BDV infection in two family clusters of patients with CFS: a father, mother, two sons and one daughter (family #1); and a father, mother, two daughters and one son (family #2). All members, except for the elder son in family #1 and the father and son in family #2, were diagnosed with CFS. The results supported that all the family members with CFS were infected with BDV, as evidenced by the presence of antibodies to viral p40, p24 and/or gp18 and BDV p24 RNA in peripheral blood mononuclear cells. The healthy members, except for the father of family #2 who was positive for antibody to p24, were all negative by both assays. Follow‐up studies in family #1 continued to reveal BDV antibodies and BDV RNA, except in the mother, who lost the RNA upon slight recovery from the disease.