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The Role of Intrahepatic γδ‐T Cells for Liver Injury Induced by Salmonella Infection in Mouse
Author(s) -
Ishigami Masatoshi,
Nishimura Hitoshi,
Yoshioka Kentaro,
Kakumu Shinichi,
Yoshikai Yasunobu
Publication year - 1999
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1999.tb02429.x
Subject(s) - biology , salmonella , liver injury , monoclonal antibody , antibody , salmonella infection , hamster , immunology , enterobacteriaceae , knockout mouse , receptor , microbiology and biotechnology , endocrinology , bacteria , escherichia coli , biochemistry , gene , genetics
Liver injury was induced after infection with Salmonella choleraesuis 31N‐1. In T‐cell receptor‐δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti‐γδ T‐cell receptor monoclonal antibody (UC7‐13D5) to stimulate γδ‐T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ‐T cells have effector activities not only for protection but also for liver injury during Salmonella infection.