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Are Autoantibodies against Lewis Antigens Involved in the Pathogenesis of Helicobacter pylori ‐lnduced Peptic Ulcers?
Author(s) -
Kamiya Kenji,
Arisawa Tomiyasu,
Goto Hidemi,
Shibayama Keigo,
Horii Toshinobu,
Hayakawa Tetsuo,
Ohta Michio
Publication year - 1999
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1999.tb02423.x
Subject(s) - autoantibody , helicobacter pylori , pathogenesis , antibody , titer , peptic , spirillaceae , immunology , antigen , medicine , gastroenterology , peptic ulcer , gastritis , biology
We examined whether anti‐Lewis x (Le x ) and y (Le y ) autoantibodies affect the pathogenesis of Helicobacter pylori ‐induced peptic ulcers. Of 11 patients with peptic ulcers, 10 patients had both anti‐Le x and ‐Le y immunoglobulin G (IgG) antibodies, and 1 patient had only anti‐Le x antibody. After successful eradication, we measured the serum titer of anti‐Le x and ‐Le y antibodies. Six patients had a reduction of the titers of anti‐Le x and/or ‐Le y antibodies, whereas no notable changes were detected in 5 patients in the follow‐up. This result suggests that anti‐Le x and ‐Le y autoantibodies had no critical role in the development of H. pylori ‐induced peptic ulcer.