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Facilitated Expansion of Pneumococcal Colonization from the Nose to the Lower Respiratory Tract in Mice Preinfected with Influenza Virus
Author(s) -
Takase Hiroyuki,
Nitanai Hironobu,
Yamamura Eiko,
Otani Tsuyoshi
Publication year - 1999
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1999.tb01226.x
Subject(s) - respiratory tract , streptococcus pneumoniae , nose , biology , virus , nasal administration , colonization , microbiology and biotechnology , inoculation , virology , respiratory system , influenza a virus , respiratory tract infections , immunology , anatomy , antibiotics
A strain of Streptococcus pneumoniae , when inoculated intranasally in 2 μl of suspension into BALB/c mice preinfected with influenza virus, colonized first in the nose, and several days thereafter also colonized significantly in the trachea and lungs with purulent inflammation. Pneumoccocal colonization was also observed in the noses of normal mice after the same bacterial inoculation, but not apparently in the lower respiratory tract. These results suggest that pneumococcal infection may develop from the upper to the lower respiratory tract as a possible sequence preferentially in influenza virus‐infected subjects.