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Transient Dissociation between Infectious HIV‐1 Titer and Viral RNA during the Early Phase of AZT Treatment
Author(s) -
Zöllner Bernhard,
Stellbrink HansJürgen,
Feucht Heinzhubert,
Schröter Matthias,
Baumgartner Evamaria,
Laufs Rainer
Publication year - 1998
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1998.tb02311.x
Subject(s) - infectivity , titer , virology , biology , human immunodeficiency virus (hiv) , antigen , zidovudine , viral load , lentivirus , immunology , virus , viral disease
The short‐term kinetics of infectious HIV titers, HIV copy numbers and p24‐antigen during the first 28 days of AZT monotherapy were evaluated. In three of four patients, infectious HIV was culturable and infectious titers rose 2‐ and 4‐fold compared to baseline values. This increase was neither associated with mutations conferring resistance to AZT nor a switch from NSI to SI phenotypes. Two patients showed an increase of plasma infectivity associated with a reduction of HIV copies and p24‐antigen. We conclude that transient dissociations of plasma infectivity and HIV copy numbers occur during early AZT monotherapy.