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Cellular Reaction to Mycobacterium avium Complex (MAC) Clinical Isolates Differing in Hemolytic Activity and Virulence for C57BL/6 Mice
Author(s) -
Brzychcy Marzena,
Zwolska Zofia,
Andrzejczyk Zofia,
Rudnicka Wiesława
Publication year - 1998
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1998.tb02295.x
Subject(s) - virulence , biology , microbiology and biotechnology , hemolysin , in vivo , in vitro , mycobacterium bovis , cytotoxicity , bacilli , mycobacterium , macrophage , virology , mycobacterium tuberculosis , bacteria , tuberculosis , gene , medicine , biochemistry , genetics , pathology
Abstract In this study we showed that Mycobacterium avium complex (MAC) clinical isolates differed by the expression of hemolytic activity. Two hemolytic MAC strains were less susceptible to the mycobactericidal effect of murine macrophages than two unhemolytic MAC isolates. In vivo , hemolytic MAC bacilli survived in the spleens of infected mice for a longer time than unhemolytic MAC strains. This suggested a role of hemolysins in the virulence of MAC strains. There was no difference in the cytotoxicity of T cells from mice immunized with M. bovis BCG towards macrophages infected in vitro with MAC strains expressing or not expressing hemolytic activity.