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Pathogenicity of a Mutant Friend Spleen Focus‐Forming Virus Encoding an Env‐Like Membrane Glycoprotein (gp55) with Substitution by a Xenotropic Murine Leukemia Virus Env gp70 Sequence
Author(s) -
Yugawa Takashi,
Amanuma Hiroshi
Publication year - 1998
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1998.tb02292.x
Subject(s) - murine leukemia virus , biology , retrovirus , virology , virus , mink , friend virus , glycoprotein , mutant , gammaretrovirus , feline leukemia virus , gene , group specific antigen , mutation , microbiology and biotechnology , genetics , ecology
Friend spleen focus‐forming virus (F‐SFFV) is a replication‐defective acutely leukemogenic mouse retrovirus and encodes an envelope protein (Env)‐like membrane glycoprotein (gp55) in its defective env gene, which is responsible for the early stage of the viral leukemogenesis. Gp55 is a modified Env protein and contains a polytropic mink cell focus‐inducing (MCF) murine leukemia virus (MuLV) Env gp70‐derived sequence in its amino‐terminal region. To evaluate the possibility that the presumed binding of gp55 to an MCF MuLV receptor protein has some role in leukemogenesis, we examined the biological activities of a mutant gp55 (XE gp55), which has a xenotropic MuLV Env gp70 amino‐terminal region. XE gp55 displayed almost the same biological activities as the wild‐type gp55, excluding the above possibility.