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Infectivity and Arthritis Induction of Borrelia japonica on SCID Mice and Immune Competent Mice: Possible Role of Galactosylceramide Binding Activity on Initiation of Infection
Author(s) -
Kaneda Kazuhide,
Masuzawa Toshiyuki,
Simon Markus M.,
Isogai Emiko,
Isogai Hiroshi,
Yasugami Kitsuzo,
Suzuki Takashi,
Suzuki Yasuo,
Yanagihara Yasutake
Publication year - 1998
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1998.tb02268.x
Subject(s) - infectivity , biology , virulence , borrelia burgdorferi , arthritis , microbiology and biotechnology , immune system , japonica , strain (injury) , virology , immunology , antibody , virus , gene , botany , anatomy , biochemistry
We investigated the relationship between the binding activity to galactosylceramide (GalCer) and the arthritis induction activity of Borrelia japonica . The B. japonica strains maintained the ability to induce arthritis in inbred C3H/HeN and immunodeficient SCID mice, but the ability was lower than that of Borrelia burgdorferi sensu stricto virulent strain 297. Histopathological changes were restricted to the joints, and a marked effusion of polymorphonuclear neutrophils into the joint space was found. The binding activity of B. japonica strains to GalCer was lower than that of the virulent strain 297 but higher than that of the high‐passage strain 297. The lower infectivity and virulence of B. japonica may explain its lower binding ability to GalCer.