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Cloning and Characterization of the Genomic RNA Sequence of the Mumps Virus Strain Associated with a High Incidence of Aseptic Meningitis
Author(s) -
Saito Hiroyuki,
Takahashi Yoshihiro,
Harata Seizaburo,
Tanaka Keiko,
Sato Hiroyasu,
Suto Tsunehisa,
Yamada Akio,
Yamazaki Shudo,
Morita Morihiro
Publication year - 1998
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1998.tb02262.x
Subject(s) - virology , biology , strain (injury) , mumps virus , aseptic meningitis , mumps vaccine , virus , microbiology and biotechnology , vaccination , rubella , measles , cerebrospinal fluid , neuroscience , anatomy
cDNA clones of the mumps virus wild‐type strain, associated with a high incidence of aseptic meningitis (ODATE‐1 strain), were isolated and analyzed from genomic nucleotide position 22 to 8520 containing the NP, P, M., F, SH and HN protein coding region. The ODATE‐1 strain exhibited a RFLP profile identical to that of the Urabe vaccine strain in spite of the fact that the virus was isolated from non‐vaccinated cases. However, a comparison of nucleotide and amino acid sequences among the ODATE‐1 strain, Urabe strain and Miyahara strain revealed that the ODATE‐1 strain was not related to the Urabe strain.