Premium
Role of Curdlan Sulfate in the Binding of HIV‐1 gp120 to CD4 Molecules and the Production of gp120‐Mediated TNF‐α
Author(s) -
TakedaHirokawa Nanako,
Neoh Lianpin,
Akimoto Hiroaki,
Kaneko Hiroshi,
Hishikawa Takashi,
Sekigawa Iwao,
Hashimoto Hiroshi,
Hirose Shunichi,
Murakami Tsutomu,
Yamamoto Naoki,
Mimura Tohru,
Kaneko Yutaro
Publication year - 1997
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1997.tb01920.x
Subject(s) - curdlan , biology , human immunodeficiency virus (hiv) , tumor necrosis factor alpha , virus , microbiology and biotechnology , viral replication , virology , biochemistry , immunology , polysaccharide
To clarify the mechanism by which curdlan sulfate (CRDS) inhibits human immunodeficiency virus (HIV)‐1 infection, we examined its influence on the binding of gp120 to CD4 molecules on T cells and macrophages, as well as on the production of TNF‐α by gp120‐stimulated macrophages (which promotes HIV‐1 replication). CRDS treatment of cells not only inhibited the binding of HIV‐1 gp120 to CD4 + cells, but also inhibited TNF‐α production induced by gp120. Inhibition of HIV‐1 infection by CRDS may be related to these two actions.