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Replication of Feline Syncytial Virus in Feline T‐Lymphoblastoid Cells and Induction of Apoptosis in the Cells
Author(s) -
Ikeda Yasuhiro,
Itagaki Shinlchi,
Tsutsui Shigeki,
Inoshima Yasuo,
Fukasawa Masashi,
Tomonaga Keizo,
Tohya Yukinobu,
Maeda Ken,
Mochizuki Masami,
Miyazawa Takayuki,
Mikami Takeshi
Publication year - 1997
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1997.tb01875.x
Subject(s) - biology , lymphoblast , virology , peripheral blood mononuclear cell , feline immunodeficiency virus , apoptosis , virus , cats , microbiology and biotechnology , cell culture , lentivirus , viral disease , genetics , medicine , in vitro
Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV‐seropositive cats. When the susceptibility of feline T‐lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV‐infected T‐lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.