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Recombinant Interleukin‐1 Promotes Leishmaniasis in Susceptible Mice
Author(s) -
Ajdary Soheila,
Hosseini Mohammad Hossein,
Alimohammadian Mohammad Hossein
Publication year - 1997
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1997.tb01202.x
Subject(s) - biology , recombinant dna , leishmania , leishmaniasis , leishmania major , interleukin , immunology , interleukin 4 , interleukin 2 , prostaglandin , prostaglandin e2 , cytokine , parasite hosting , endocrinology , biochemistry , world wide web , gene , computer science
Interleukin‐1 exacerbates leishmanial lesions in Leishmania major ‐infected BALB/c mice. Indomethacin can modulate the effect of IL‐1, so at least part of the IL‐1 effect on disease progression is due to the induction of prostaglandin synthesis.