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Production of a T‐Cell Clone Which Reacts with Membrane Proteins of Acholeplasma laidlawii
Author(s) -
Kuwano Koichi,
Ono Saori,
Akashi Akira,
Ohishi Masahiro,
Shigematsu Hideki,
Arai Sumio
Publication year - 1997
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1997.tb01198.x
Subject(s) - biology , clone (java method) , mycoplasma , t cell receptor , immune system , mollicutes , cellular immunity , microbiology and biotechnology , t cell , immunity , mycoplasmataceae , mycoplasma pneumoniae , cell , virology , immunology , gene , biochemistry , history , archaeology , pneumonia
The role of cellular immunity in mycoplasma infection is not completely understood. In this study, we established mycoplasma‐specific T‐cell clones to evaluate cellular immunity in mycoplasma infection. We developed a T‐cell clone (G‐10) which was stimulated with Acholeplasma laidlawii . The T‐cell clone G‐10, CD4 + and T‐cell receptor (TCR) αβ + recognized the 42‐ and 65‐kilodalton (kDa) membrane proteins of A. laidlawii and responded to A. hippikon . Hence, the application of mycoplasma‐specific T cells such as G‐10 in animal models may allow the assessment of cellular immune response to mycoplasma infection.