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Previous Enteric Adenovirus Infection Does Not Protect against Subsequent Symptomatic Infection: Longitudinal Follow‐up of Eight Infants
Author(s) -
Unicomb Leanne E.,
JareckiKhan Kerstin,
Hall Andrew,
Podder Goutham
Publication year - 1996
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1996.tb03320.x
Subject(s) - diarrhea , serotype , adenovirus infection , antibody , biology , virology , enteric virus , immunology , medicine , virus
Eight infants followed longitudinally were found to have enteric adenovirus (EAdv) infections: in 5 infants with diarrhea and in 3 with no accompanying diarrhea. Sequential stool samples prior to EAdv infections were tested for adenovirus antigen, anti‐adenoviral IgA and neutralizing antibodies to serotypes 40, 41 and 2 in order to ascertain whether protection from symptoms was due to prior infection. No difference was found in the number of adenoviral infections among infants prior to their EAdv infections with or without accompanying diarrhea. However, in 3 of the 5 infants in whom EAdv infection was accompanied by diarrhea and 2 of 3 control infants, previous EAdv infections had occurred as detected by serotype‐specific antibody rises.