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Proliferation and Teratogenicity of Aino Virus in Chick Embryos
Author(s) -
Kitano Yoshio,
Ohzono Hiroyuki,
Shimizu Tsutomu
Publication year - 1996
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1996.tb03309.x
Subject(s) - biology , titer , embryo , virus , hydranencephaly , yolk sac , inoculation , andrology , cerebellar hypoplasia (non human) , fetus , anatomy , virology , cerebellum , endocrinology , pregnancy , immunology , medicine , genetics , microbiology and biotechnology
Aino virus (AIV; JaNAr 28 strain) 10 3 TCID 50 /0.2 ml was inoculated in the yolk sac of 8‐day‐old chick embryos. Recovery and titration of the virus from various organs including the central nervous system (CNS) and skeletal muscle were performed at 2, 4, 7, 10 and 13 days after inoculation (PI). AIV was systemically disseminated and proliferated even 2 days PI. The titers of the recovered virus from the CNS and from skeletal muscle was the highest at 4 days PI and declined with time, whereas hydranencephaly, arthrogryposis and cerebellar hypoplasia developed at 7 days PI and gradually progressed until 13 days PI.