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Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa
Author(s) -
Tanaka Yasushi,
Yazawa Katsukiyo,
Dabbs Eric R.,
Nishikawa Kazutaka,
Komaki Hisayuki,
Mikami Yuzuru,
Miyaji Makoto,
Morisaki Naoko,
Iwasaki Shigeo
Publication year - 1996
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1996.tb03303.x
Subject(s) - nocardia , rifampicin , microbiology and biotechnology , rhodococcus , biology , bacteria , corynebacterium , antibiotics , mycobacterium , mycolic acid , genetics
Mycolic acid‐containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species‐specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast‐growing Mycobacterium modified rifampicin by ribosylation of the 23‐OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium , but phosphorylation of the 21‐OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23‐OH group) and phosphorylation, but ribosylation was not observed.