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Kinetics of Organ‐Associated Natural Killer Cells and Intermediate CD3 Cells during Pulmonary and Hepatic Granulomatous Inflammation Induced by Mycobacterial Cord Factor
Author(s) -
Tabata Akihiro,
Kaneda Kenji,
Watanabe Hisami,
Abo Toru,
Yano Ikuya
Publication year - 1996
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1996.tb01123.x
Subject(s) - biology , cd3 , inflammation , interleukin 12 , immunology , natural killer t cell , cytotoxic t cell , t cell , cd8 , immune system , biochemistry , in vitro
We investigated here the kinetics of natural killer (NK) cells and extrathymic T cells, which include intermediate CD3 cells and γδ T cells, in the cord factor‐induced granulomatous inflammation of the lungs and liver. In Balb/c mice, pulmonary inflammation elevated the proportion of NK cells and that of extrathymic T cells to mononuclear cells in the lungs. C3H/He mice exhibited shorter‐term inflammation of the lungs than Balb/c mice and accordingly showed a smaller increase in the proportions of pulmonary NK cells and intermediate CD3 cells. In the liver of Balb/c mice, hepatic NK cells increased as well with the granulomatous changes, while intermediate CD3 cells exhibited a transient decrease before they increased. The present study has demonstrated that granulomatous inflammation is accompanied by the increase of lung‐associated NK cells and extrathymic T cells and that there exists a difference between these two mouse strains in the induction of these lymphocyte subsets by cord factor.