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Class‐Specific Antibody Response in Acyclovir‐Treated and Adenine Arabinoside‐Treated Patients with Primary Genital Herpes Simplex Virus Infection
Author(s) -
Kawana Takashi,
Hashido Madoka,
Koizumi Yoshio
Publication year - 1995
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1995.tb03272.x
Subject(s) - herpes simplex virus , antibody , virology , simplexvirus , genital herpes , immunology , aciclovir , herpes genitalis , virus , herpesviridae , biology , immunoglobulin m , alphaherpesvirinae , antibody response , immunoglobulin g , viral disease
Herpes simplex virus (HSV) class‐specific antibody responses after primary genital herpes infection were evaluated with an enzyme‐linked immunosorbent assay (ELISA) in 16 patients treated with acyclovir (ACV), given orally, and 17 patients treated with adenine arabinoside (Ara‐A), given topically. ACV significantly suppressed the levels of IgM, IgA, and IgG. In the ACV‐treated patients, IgM and IgG were not detected in 4 of the 16 and in 1 of the 16 patients, respectively. We must take into account this suppressive effect of ACV on antibody responses, especially on the IgM response, when serodiagnosis of HSV infection is made.