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Interference between Neisseria meningitidis and PC‐KLH Induced Anti‐Phosphorylcholine PFC Responses in NZB/W Autoimmune Mice
Author(s) -
Seoane Rafael,
Eiras Adolfo,
Quireza Otilia,
Cancio Esperanza,
Aguilera Antonio,
Puentes Eugenia
Publication year - 1995
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1995.tb02233.x
Subject(s) - neisseria meningitidis , phosphorylcholine , idiotype , clone (java method) , biology , antigen , immunology , ratón , antibody , gene , monoclonal antibody , genetics , bacteria , biochemistry
In this work, we demonstrate that the simultaneous injection of PC‐KLH and Neisseria meningitidis ‐derived antigens [NMB or PC‐(NMB)HI] induced in old NZB/W mice defective responses as does PC‐KLH challenge. On the other hand, the simultaneous injection of both immunogenic preparations of N. meningitidis evoked responses similar to those shown by old mice challenged with NMB alone. Alteration in PC‐specific PFC responses also affected hapten‐free inhibition profiles and their heterogeneities. The increase in PC 50 s of anti‐phosphorylcholine PFC responses and their heterogeneities induced by certain antigens with aging is correlated with a decrease in T15 idiotype expression, suggesting that after the T15 dominant clone disappears no other clone takes control of the anti‐PC response. These results suggest that the mechanism(s) involved in the regulation of T15 marker expression play an important role in the inability of old NZB/W mice to mount good anti‐PC responses and suggest that regulatory mechanisms induced by PC‐KLH dominate those elicited by NMB.