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Conspicuous Growth of Intravenously Inoculated Staphylococcus aureus in Subcutaneously Established Ehrlich Ascites Tumor Tissue of Mice
Author(s) -
Murai Miyo,
Seki Keiko,
Sakurada Junji,
Usui Akemi,
Masuda Shogo
Publication year - 1995
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1995.tb02182.x
Subject(s) - staphylococcus aureus , biology , kidney , inoculation , staphylococcal infections , pathology , microbiology and biotechnology , immunology , bacteria , endocrinology , medicine , genetics
Intratumoral growth of Staphylococcus aureus was compared with the intrarenal growth, to examine the usefulness of the method as a marker of its pathogenicity. When 5 × 10 7 CFU/mouse of three derivatives from S. aureus Cowan I with different intrarenal growth were intravenously injected into Ehrlich tumor‐bearing mice, they lodged in the tumor tissue at approximately 10 3 CFU/0.1 g by 30 min after infection, and grew in the range of 10 6 CFU/0.1 g to 10 8 CFU/0.1 g by day 4, regardless of their intrarenal growth capacity. In contrast, S. saprophyticus lodged in both tissues to the same degree as S. aureus , but did not grow at all. The time course of the staphylococcal growth was different between tumor tissue and kidney, suggesting differences in the local responses against S. aureus .