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Augmentation of Host Resistance against Bacterial Infection by Treatment with Leustroducsin B, a New CSF Inducer
Author(s) -
Kohama Takafumi,
Katayama Toshiaki,
Inukai Masatoshi,
Maeda Hiroaki,
Shiraishi Akio
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01850.x
Subject(s) - inducer , biology , microbiology and biotechnology , escherichia coli , in vivo , host (biology) , escherichia coli infection , cytokine , superoxide , in vitro , immunology , gene , biochemistry , enzyme , genetics
We tested the in vivo activity of leustroducsin B (LSN B), a new colony‐stimulating factor (CSF) inducer isolated from the culture broth of Streptomyces platensis , with mice infected with Escherichia coli. Treatment with LSN B augmented the host resistance to lethal infection of E. coli at doses between 0.1 mg/kg and 1 mg/kg. Serum interleukin‐6 (IL‐6) levels were found to increase after this treatment, and superoxide anion generation of neutrophils was enhanced in vivo , suggesting that LSN B augmented the host resistance at least in part by inducing IL‐6, which subsequently enhanced the bactericidal activity of the neutrophils.