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Elevated Plasma Levels of P‐Selectin (GMP‐140/CD62P) in Patients with Plasmodium falciparum Malaria
Author(s) -
Facer Christine A.,
Theodoridou Agapi
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01848.x
Subject(s) - parasitemia , malaria , plasmodium falciparum , cerebral malaria , p selectin , platelet , biology , immunology , medicine , severe malaria , platelet activation
The plasma concentration of soluble P‐selectin (GMP‐140/CD62P/PADGEM), a selectin produced by activated platelets and endothelial cells, was quantitated in a group of adults and East African negro children presenting with either non‐severe or severe (cerebral) malaria caused by Plasmodium falciparum. Sixty percent of adults with non‐severe malaria had immunoreactive levels of P‐selectin above 200 ng/ml (the maximum recorded for any normal healthy adult in the assay) and 86 % of all African children with malaria had concentrations above normal irrespective of their clinical categorization, and most exceeded the maximum limits of the assay (> 640 ng/ml). There was no correlation between P‐selectin levels and parasitemia. These results raise the possibility that elevated soluble P‐selectin in malaria may have an important beneficial antiinflammatory function.