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Stimulation of Macrophage Oxygen Free Radical Production and Lymphocyte Blastogenic Response by Immunization with Porins
Author(s) -
Tabaraie Bahman,
Sharma Bal Krishan,
Sharma Praveen Rishi nee,
Sehgal Rakesh,
Ganguly Nirmal Kumar
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01823.x
Subject(s) - stimulation , immunology , biology , macrophage , immunization , lymphocyte , microbiology and biotechnology , immune system , biochemistry , endocrinology , in vitro
Porins were prepared from smooth strain of Salmonella typhi 0–901 and chemotype rough mutant of S. typhimurium Ra‐30. Porins could significantly stimulate the immune systems of mice. Immunization of mice with the porins provoked synthesis of anti‐porin antibodies. Macrophages from the immunized mice showed increased capacity to generate oxygen free radicals, and lymphocytes from these mice showed proliferative response to the porins. Thus porins may play a role in providing protection from salmonellosis by stimulating the antibody production and increasing the capacity of macrophages to generate oxygen free radicals along with stimulation of lymphocytes.