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Evaluation of Salmonella Porins as a Broad Spectrum Vaccine Candidate
Author(s) -
Tabaraie Bahman,
Sharma Bal Krishan,
Sharma Praveen Rishi nee,
Sehgal Rakesh,
Ganguly Nirmal Kumar
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01822.x
Subject(s) - porin , microbiology and biotechnology , biology , heterologous , salmonella enteritidis , salmonella , bacterial outer membrane , salmonella typhi , mutant , enterobacteriaceae , strain (injury) , virology , bacteria , escherichia coli , genetics , gene , anatomy
Porins were prepared from smooth strain of Salmonella typhi 0–901 and chemotype of rough mutant of S. typhimurium Ra‐30. Mice were immunized with both the porin preparations in different groups and challenged with S. typhimurium LT2–71 and S. enteritidis SH‐1269. Porin immunized mice showed significant protection ( P <0.01) against challenge with homologous as well as heterologous strains. Hence, the use of porins may be attempted in future to protect against salmonellosis.