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Modulation by Polymyxin B of the Effects of Interferon on Human Myelogenous Leukemia Cells
Author(s) -
Tamura Minori,
Nagano Yasuiti
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01800.x
Subject(s) - recombinant dna , biology , polymyxin , polymyxin b , interferon , microbiology and biotechnology , leukemia , in vitro , cell culture , virology , immunology , antibiotics , biochemistry , genetics , gene
Abstract Natural and recombinant human interferon‐α (IFN‐α) and ‐γ (IFN‐γ) exert differentiation‐inducing and cytocidal effects in vitro on cells of the human myeloblastic leukemia cell line ML‐2. These activities of IFNs are modulated by polymyxin B (PMB), a cyclic polycationic peptide antibiotic effective on Gram‐negative bacilli. The modulating effect of PMB varies according to the species of IFN, namely, PMB enhances the activities of either natural IFN‐γ or recombinant IFN‐γ, while it inhibits the effects of either natural IFN‐α or recombinant IFN‐α. The cause of this variety in PMB effect on IFNs remains to be clarified.