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In Vitro Antibiotic Susceptibilities of Borrelia Isolates from Erythema Migrans Lesion of Lyme Disease Patients in Japan
Author(s) -
Masuzawa Toshiyuki,
Yamada Kazuto,
Kawabata Hiroki,
Yanagihara Yasutake
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01798.x
Subject(s) - erythema migrans , microgram , lyme disease , minocycline , borrelia , broth microdilution , microbiology and biotechnology , antibiotics , erythromycin , amoxicillin , biology , erythema , penicillin , cefaclor , borrelia burgdorferi , minimum inhibitory concentration , virology , in vitro , cephalosporin , immunology , antibody , lyme borreliosis , biochemistry
Antibiotic susceptibilities of twelve borrelial isolates from skin of patients with erythema migrans (EM) and ticks ( Ixodes persulcatus and I. ovatus ) in Japan were examined by in vitro microdilution MIC method and macrodilution MBC method. Nine EM isolates and 3 tick isolates were susceptible to amoxicillin, erythromycin, and minocycline. MICs for Japanese isolates were 0.038–0.30 μg/ml, < 0.012 μg/ml, and < 0.012–0.05 μg/ml, respectively. MBCs were as follows: 0.038–0.88 μg/ml, < 0.012–0.10 μg/ml, and <0.025–0.78 μg/ml, respectively. These antibiotics could be recommended for treatment of patients in early stage of Lyme disease in Japan.