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Immunological Recognition of Fibronectin‐Binding Proteins of Staphylococcus aureus and Staphylococcus capitis , Strain LK499
Author(s) -
Sakata Noriaki,
Rozalska Barbara,
Wadström Torkel
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01791.x
Subject(s) - staphylococcus aureus , microbiology and biotechnology , biology , strain (injury) , protein a , antibody , micrococcaceae , staphylococcus , staphylococcal infections , bacteria , immunology , genetics , anatomy
Antibodies to fibronectin‐binding proteins (FnBPs) of Staphylococcus aureus , including binding domain of FnBPA, the D region, or the A‐C regions of FnBPB were produced in rabbits and mice. These antibodies were used to characterize cell‐associated FnBPs of S. aureus strain Cowan I, S. aureus strain U320 and a coagulase‐negative Staphylococcus capitis strain LK499 as well as extracellular FnBPs in culture supernatants of the strain U320. FnBPs of S. aureus were predominantly FnBPA, while FnBPB was hardly detected on the cells or in culture supernatant of these S. aureus strains. Moreover, S. capitis strain LK499 possessed different FnBP(s) compared to S. aureus because the antibodies to S. aureus FnBPs did not recognize FnBP(s) on S. capitis.