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Amniotic Fluid Enhances Allogeneic Cytotoxic T Cell Responses, Whereas It Suppresses Mitogen‐Stimulated Lymphocyte Proliferation
Author(s) -
Parvin Mahbuba,
Isobe Kenichi,
Zohreh Heidari,
Goto Setsuko,
Nakashima Izumi,
Tomoda Yutaka
Publication year - 1994
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1994.tb01786.x
Subject(s) - ctl* , cytotoxic t cell , amniotic fluid , immunology , biology , lymphocyte , t lymphocyte , transplantation , antigen , pregnancy , andrology , fetus , medicine , cd8 , in vitro , biochemistry , genetics
Mouse amniotic fluid has been shown to suppress T lymphocyte proliferation and suggested to be important in regulating immunity during pregnancy. In allogeneic pregnancy, cytotoxic T cells in pregnant lymphocytes against paternal transplantation antigen are impaired. We examined the effect of amniotic fluid to the alloreactive CTL responses. Although the amniotic fluid suppressed Con A or LPS stimulated lymphocyte proliferation as previously reported, the amniotic fluid taken from syngeneic C57BL/6 pregnant mice or allogeneic C57BL/6 × BALB/c pregnant mice enhanced the anti‐H‐2 d or anti‐H‐2 k CTL responses dose‐dependently. We speculate that amniotic fluid contains not only immunosuppressive factors but also immunoenhancing factors which upregulate the allogeneic CTL responses.