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Effect of Clostridium perfringens Epsilon Toxin on Rat Isolated Aorta
Author(s) -
Nagahama Masahiro,
Iida Hiroshi,
Sakurai Jun
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb03235.x
Subject(s) - methysergide , clostridium perfringens , contraction (grammar) , phentolamine , toxin , tetrodotoxin , aorta , prazosin , biology , muscle contraction , pharmacology , microbiology and biotechnology , medicine , anatomy , endocrinology , antagonist , biochemistry , stimulation , receptor , bacteria , genetics
The effect of Clostridium perfringens epsilon toxin on rat isolated aorta was investigated. The toxin caused contraction of the isolated aorta in a dose‐dependent manner. The toxin induced no contraction of the isolated aorta in low‐Na medium and of the tissue stored at 4 C for 7 days. However, tetrodotoxin (TTX) had no effect on the toxin‐induced contraction. The toxin‐induced contraction was significantly inhibited by phentolamine and prazosine, but did not by atropine, mecamylamine, chlorpheniramine and methysergide. These data suggest that the toxin‐caused contraction is mediated through nervous system in rat isolated aorta.