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Identification and Characterization of Heat‐Stable Enterotoxin II‐Producing Escherichia coli from Patients with Diarrhea
Author(s) -
Okamoto Keinosuke,
Fujii Yoshio,
Akashi Noriko,
Hitotsubashi Shunji,
Kurazono Hisao,
Karasawa Tadahiro,
Takeda Yoshifumi
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb03230.x
Subject(s) - enterotoxin , enterotoxigenic escherichia coli , escherichia coli , biology , diarrhea , antiserum , microbiology and biotechnology , heat stable enterotoxin , enterobacteriaceae , gene , antigen , biochemistry , genetics , medicine
Stock strains of Eschericia coli isolated from patients with traveller's diarrhea were examined for production of heat‐stable enterotoxin II (STII). Of 400 strains examined, 3 were found to produce STII. The nucleotide sequence of the STII gene of these human strains was shown to be identical to that of porcine strains. Cultured cells of these strains induced fluid accumulation in ligated mouse intestinal loops and the activity was neutralized by anti‐STII antiserum. These results suggest that STII‐produciing enterotoxigenic E. coli can cause human diarrhea.