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Neurologic Abnormalities in Two Dogs Suspected Lyme Disease
Author(s) -
Azuma Yuzo,
Kawamura Katsuzi,
Isogai Hiroshi,
Isogai Emiko
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb03217.x
Subject(s) - borrelia burgdorferi , lyme disease , ixodes persulcatus , titer , lyme , immunology , biology , borrelia burgdorferi infection , penicillin , antibody , tick , antibody titer , spirochaetaceae , virology , antibiotics , microbiology and biotechnology
A 2‐year‐old mongrel dog developed neurological signs following tick bite. These included astasia, persistent tonic convulsions and hyper‐reflexia. Both serum IgG and IgM antibody titers against Borrelia burgdorferi were positive in enzyme‐linked immunosorbent assay (ELISA). The neurological signs subsided after high‐dose penicillin and streptomycin treatment. A strain of spirochetes (P427a) was isolated from the midgut of Ixodes persulcatus feeding on the dog. Morphological characteristic, immunological property and protein profile revealed that the isolate was B. burgdorferi . Similarly, a 2‐year‐old Labrador retriever dog developed neurological signs after tick bite and showed a positive IgG antibody titer against B. burgdorferi . Antibiotic treatment was effective also in this case. These findings suggest that neurological symptoms shown in both dogs were caused by infection with B. burgdorferi .