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Fibronectin‐Binding Proteins of a Human Oral Spirochete Treponema denticola
Author(s) -
Umemoto Toshihiko,
Nakatani Yoshihiro,
Nakamura Yoshinori,
Namikawa Isamu
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb03182.x
Subject(s) - treponema denticola , fibronectin , biology , treponema , polyacrylamide gel electrophoresis , microbiology and biotechnology , sodium dodecyl sulfate , gel electrophoresis , biochemistry , bacteria , extracellular matrix , virology , enzyme , genetics , porphyromonas gingivalis , syphilis , human immunodeficiency virus (hiv)
Major polypeptides from a human oral spirochete Treponema denticola ATCC 33520 were examined to demonstrate their ability to bind to human plasma fibronectin by immunoblot analysis. Of three main polypeptides separated on sodium dodecyl sulfate polyacrylamide gels 53,000‐daltons (53‐kDa) and 72‐kDa surface antigenic proteins and a 38‐kDa axial flagellar protein showed the ability to bind to fibronectin, suggesting that fibronectin on host cells can mediate cytoadherence of T. denticola by its binding to the surface proteins or the exposed 38‐kDa axial flageller protein.