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Small, Round‐Structured Viruses (SRSVs) Associated with Acute Gastroenteritis Outbreaks in Gifu, Japan
Author(s) -
Kawamoto Hiroyoshi,
Hasegawa Sumiyo,
Sawatari Seiko,
Miwa Chieko,
Morita Osayuki,
Hosokawa Takehiko,
Tanaka Hiroshi
Publication year - 1993
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/j.1348-0421.1993.tb01736.x
Subject(s) - outbreak , virology , biology , virus , western blot , acute gastroenteritis , antibody , microbiology and biotechnology , immunoassay , blot , bacteria , viral disease , immunology , biochemistry , genetics , gene
Two outbreaks of non‐bacterial gastroenteritis occurred in Gifu prefecture in January 1989 and in January 1991. Both outbreaks were closely related to the consumption of raw oysters, and showed similar clinical features. Small, round‐structured virus particles were found in patient stools in both outbreaks by electron microscopy. The role of these particles as the causative agents of the outbreaks were strongly suggested by immune electron microscopy and/or western‐blotting immunoassay. When compared with SRSV‐9 (Tokyo/SRSV/86–510) reported previously (Hayashi et al, J. Clin. Microbiol., 27: 1728–1733, 1989), it was found that these viral particles were antigenically similar to SRSV‐9, and had a major structural protein of 63 kilodaltons (kDa). Further, the prevalence of this agent in Gifu area was examined by western blot antibody assay using 67 serum samples collected from the inhabitants in 1991. The results indicated the circulation of the same or antigenically similar agent in this area.